Akifumi Kushiyama Selected Research

Glucose (Dextrose)

1/2022	[Metabolism-dependent Vascular Pathophysiology in Adult Diseases].
1/2021	Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis.
1/2020	Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells.
9/2019	Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice.
1/2019	Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice.
10/2017	Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.
1/2015	Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus.
6/2011	Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.
8/2006	Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.

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Akifumi Kushiyama Research Topics

Disease

18	Inflammation (Inflammations) 01/2022 - 12/2005
11	Type 2 Diabetes Mellitus (MODY) 02/2022 - 11/2013
11	Insulin Resistance 09/2019 - 12/2005
9	Obesity 01/2021 - 09/2007
8	Non-alcoholic Fatty Liver Disease 10/2018 - 12/2012
7	Atherosclerosis 01/2022 - 11/2006
6	Body Weight (Weight, Body) 01/2021 - 02/2012
6	Diabetes Mellitus 10/2017 - 09/2007
5	Hyperoxia 02/2022 - 01/2021
5	Hyperglycemia 01/2022 - 10/2010
5	Fibrosis (Cirrhosis) 01/2019 - 12/2012
4	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 01/2010
4	Alcoholic Fatty Liver 11/2019 - 01/2013
4	Glucose Intolerance 07/2013 - 12/2005
3	Diabetic Nephropathies (Diabetic Nephropathy) 02/2022 - 01/2019
3	Neoplasms (Cancer) 01/2020 - 01/2015
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2018 - 01/2013
3	Hyperuricemia 07/2015 - 06/2011
2	Diabetes Complications 02/2022 - 12/2014
2	Diabetic Angiopathies (Diabetic Angiopathy) 08/2021 - 01/2010
2	Hepatocellular Carcinoma (Hepatoma) 04/2021 - 02/2017
2	Prostatic Neoplasms (Prostate Cancer) 02/2019 - 01/2015
2	Chronic Renal Insufficiency 12/2018 - 03/2014
2	Hyperlipidemias (Hyperlipidemia) 08/2017 - 12/2005
1	Arteriosclerosis 01/2022
1	Polyneuropathies (Polyneuropathy) 08/2021
1	Liver Diseases (Liver Disease) 08/2021
1	Wounds and Injuries (Trauma) 01/2021
1	Ulcerative Colitis 01/2021
1	Colitis 01/2021
1	Chronic Kidney Failure (Chronic Renal Failure) 09/2019
1	Cardiomyopathies (Cardiomyopathy) 04/2019

Drug/Important Bio-Agent (IBA)

9	LipidsIBA 01/2022 - 01/2010
9	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 08/2006
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2005
7	Insulin (Novolin)FDA Link 01/2021 - 12/2005
6	ResistinIBA 01/2022 - 12/2005
6	Xanthine OxidaseIBA 09/2019 - 12/2014
5	Retinaldehyde (Retinal)IBA 02/2022 - 01/2021
5	Febuxostat FDA Link 09/2019 - 07/2015
4	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 01/2021 - 02/2019
4	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2020 - 01/2015
4	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2020 - 01/2015
4	Methionine (L-Methionine)FDA Link 11/2019 - 12/2013
4	Choline (Choline Chloride)IBA 11/2019 - 12/2013
4	Messenger RNA (mRNA)IBA 01/2019 - 10/2010
4	Uric Acid (Urate)IBA 01/2016 - 06/2011
3	Xanthine DehydrogenaseIBA 08/2021 - 02/2012
3	Acetyl-CoA CarboxylaseIBA 04/2021 - 02/2019
3	CytokinesIBA 01/2021 - 01/2010
3	Angiotensin Receptor AntagonistsIBA 01/2019 - 10/2012
3	Hormones (Hormone)IBA 10/2018 - 12/2005
3	Small Interfering RNA (siRNA)IBA 02/2017 - 07/2013
3	Valsartan (Vals)FDA Link 01/2013 - 02/2012
2	Biomarkers (Surrogate Marker)IBA 02/2022 - 01/2017
2	Streptozocin (Streptozotocin)FDA Link 01/2022 - 08/2017
2	SodiumIBA 01/2022 - 01/2019
2	XanthineIBA 01/2022 - 08/2021
2	Niacinamide (Nicotinamide)FDA LinkGeneric 01/2022 - 08/2017
2	NIMA-Interacting Peptidylprolyl IsomeraseIBA 01/2021 - 12/2012
2	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 06/2016
2	ThiazolidinedionesIBA 01/2020 - 01/2010
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2020 - 01/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2019 - 12/2014
2	EnzymesIBA 02/2019 - 12/2014
2	Triglycerides (Triacylglycerol)IBA 08/2017 - 01/2010
2	1,5- anhydro- 1- (5- (4- ethoxybenzyl)- 2- methoxy- 4- methylphenyl)- 1- thioglucitolIBA 08/2017 - 01/2015
2	Apolipoproteins E (ApoE)IBA 08/2017 - 01/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2017 - 12/2012
2	Alanine Transaminase (SGPT)IBA 07/2015 - 01/2015
2	Allopurinol (Remid)FDA LinkGeneric 12/2014 - 02/2012
1	CopperIBA 02/2022
1	ZincIBA 02/2022
1	6- ((4- ethylphenyl)methyl)- 3',4',5',6'- tetrahydro- 6'- (hydroxymethyl)spiro(isobenzofuran- 1(3H),2'- (2H)pyran)- 3',4',5'- triolIBA 01/2022
1	SymportersIBA 01/2022
1	Protein Subunit VaccinesIBA 01/2022
1	ApolipoproteinsIBA 01/2022
1	ReninIBA 01/2022
1	LuteinIBA 01/2022
1	HDL CholesterolIBA 08/2021
1	HypoxanthineIBA 08/2021
1	Adenosine Monophosphate (AMP)IBA 04/2021
1	Phosphotransferases (Kinase)IBA 04/2021
1	Blood Glucose (Blood Sugar)IBA 01/2021
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2021
1	Caspase 3 (Caspase-3)IBA 01/2021
1	Dextrans (Dextran)FDA Link 01/2021
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 07/2020
1	GlucosidasesIBA 01/2020
1	Dipeptidyl-Peptidase IV InhibitorsIBA 01/2020
1	Sodium-Glucose Transport ProteinsIBA 01/2020
1	Pyruvic Acid (Pyruvate)IBA 01/2020
1	AMP-Activated Protein KinasesIBA 01/2020
1	AlbuminsIBA 09/2019

Therapy/Procedure

4	Therapeutics 01/2022 - 07/2015
3	Glycemic Control 06/2016 - 11/2013
1	Lasers (Laser) 01/2022
1	Renal Dialysis (Hemodialysis) 01/2021
1	Oral Administration 01/2021
1	Ambulatory Care (Outpatient Care) 07/2020